ML-7 hydrochloride (ML-7 HCl),又称ML-7盐酸盐,是一种萘磺酰胺衍生物,是肌球蛋白轻链激酶MLCK可逆的、ATP竞争性的抑制剂 (IC50 = 300 nM)。MLCK通路在心血管疾病的发展和I/R损伤中有重要作用。此外,ML-7还可抑制PKA和PKC,Ki值分别为21 μM和42 μM。
参考文献
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冰袋运输。粉末直接保存于-20℃,有效期2年。建议分装后-20℃干燥保存,避免反复冻融。