CCL2, also called monocyte chemotactic protein (MCP1) or JE, is a member of the C?C or beta  chemokine family that is best known as a chemotactic agent for mononuclear cells . Human CCL2 cDNA encodes a 99 amino acid (aa) precursor protein with a 23 aa signal peptide and a 76 aa mature protein . Removal of the first 5 aa of the mature protein, including the N-terminal pyrrolidone carboxylic acidmodified glutamine, occurs naturally by metalloproteinase cleavage and down?regulates activity but not receptor binding. CCL2 may form multiple bands from 8.73.5 kDa on SDS?PAGE due to non?covalent dimerization and variable carbohydrate content. Mature human CCL2 shares 78?79% aa identity with canine, porcine and equine CCL2, while mouse and rat express a form of CCL2 that is extended by 49 aa and shares only 56% aa identity within the common region. Human CCL2 can, however, induce a response in murine cells.

高纯度、高活性、低内毒素、高批间一致性

-25 ~ -15℃保存，收到货之后有效期1年。 复溶后，无菌条件下，2~8℃保存，7天有效期。复溶后， 无菌条件下，-85 ~ -65℃保存，3个月有效期。