生长/分化因子 8 (GDF8),又称肌生长抑制素,可负向调节肌肉质量。GDF8 通过与其 N 端前结构域相互作用而处于潜伏状态。与众多 TGF-β 家族成员一样,GDF8 是一种二硫键连接二聚体,合成为前体蛋白,需要通过弗林样蛋白酶裂解才能产生 N 端前结构域和 C 端成熟的信号传导结构域。
高纯度、高活性、低内毒素、高批间一致性
Cell Based Assay
Figure 1. Determined by its ability to inhibit the proliferation of MPC-11 cells.
The expected ED50 for this effect is <30 ng/ml
ELISA Data
Figure 2. Immobilized Human/Mouse/Rat GDF-8, No Tag at 2 μg/ml (100 μl/well) on the plate.
Dose response curve for Human Activin RIIA, hFc Tag with the EC50 of 0.13 μg/ml determined
by ELISA.
SPR Data
Figure 3. Anti-GDF8 Antibody, hFc-Avi Tag captured on CM5 Chip via Protein A can bind
Human/Mouse/Rat GDF-8, No Tag with an affinity constant of 49.45 pM as determined in
SPR assay.
-25 ~ -15℃保存,收到货之后有效期1年。 复溶后, -85 ~ -65℃保存,3个月有效期。